Figure 2.

Histomorphological features of nephropathy in ZDF rats. In the placebo group (panel a), segmental glomerular fibrosis was frequently observed together with adjacent synechia and rarefaction of the remnant glomerulus. A neighbouring tubulus (arrow) is atrophic and shows thickening of basal membrane. Diabetic nephropathy was ameliorated in the AVE7688 group, as illustrated by two normal glomeruli in panel b. An adjacent tubulus shows a few enlarged cells with a clear cytoplasm (Armanni–Epstein cells, arrow), indicating a history of diabetes and glucosuria. Bars indicate 50 μm.