Figure 3.

(a) Effect of 1 μM eliprodil on QT_c interval of the volume-conducted ECG recorded in isolated Langendorff-perfused rabbit heart in the absence and presence of 10 μM BaCl₂ (mean±s.e.m., ^*P<0.05 eliprodil or BaCl₂ vs control in normal Locke's solution, ^†P<0.05 eliprodil in solution containing 10 μM BaCl₂ vs eliprodil in normal Locke's solution, ^‡P<0.05 BaCl₂ vs BaCl₂ and eliprodil in the organ bath). (b) The percentage change of the eliprodil-evoked QT_c lengthening in normal and in attenuated repolarisation reserve preparations. The changes in the attenuated repolarisation reserve preparations was calculated by using values as baseline after application of 10 μM BaCl₂.