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. 2004 Aug 9;143(1):43–52. doi: 10.1038/sj.bjp.0705912

Figure 4.

Figure 4

(a) Dose-dependent inhibition of leukocyte infiltration in zymosan A-induced peritonitis by intravenous administration of 3-oxa-ATL analog ZK-996 (grey bars) and ZK-990 (black bars). ZK-996 and ZK-990 were administered by tail vein 5 min prior to i.p. administration of 1 mg zymosan A. After 2 h, the peritoneum was lavaged with 5 ml sterile phosphate-buffered saline and peritoneal exudate cells were enumerated. Values are expressed as the % inhibition of the leukocyte number in vehicle-treated mice (5.8±0.5 × 106 leukocytes). Values are means±s.e.m., n=3–7 (* significantly different from vehicle, P⩽0.05). (b) Inhibition of leukocyte infiltration in zymosan A-induced peritonitis by intravenous administration of (50 μg kg−1) ATLa2, and 3-oxa-ATL analogs ZK-996 and ZK-990. Values are expressed as the % inhibition of the leukocyte number in vehicle-treated mice (5.8±0.5 × 106 leukocytes). Values are means±s.e.m., n=3–5 (* significantly different from ATLa2; P⩽0.05).