Figure 1.

Vasoconstriction to S1P in mesenteric arteries from intact aged vs young female rats. Mesenteric arteries from intact aged or young female rats were assessed for constriction in response to increasing concentrations of S1P. Data from intact aged (n=9) and young (n=6) animals are summarized and expressed as the mean±s.e.m. percent decrease in lumen diameter at each S1P concentration compared to arteries in the absence of S1P. Passive unpressurized vessel diameters (μm) in each group were similar (intact aged: 201±12.7 and young: 217±5.92). A significant difference between the curves as measured by ANOVA is denoted by an asterisk (P<0.05).