Table 1.
Resting cardiovascular variables in Experiment 1
| Group 1 (n=8) vehicle | Group 1 (n=8) Indo | Group 2 (n=17) saline | Group 2 (n=17) L-NAME | Group 3 (n=8) saline | Group 3 (n=8) AII+AVP | |
|---|---|---|---|---|---|---|
| Heart rate (beats min−1) | 330±10 | 297±12 | 343±12 | 293±13* | 344±15 | 294±14* |
| Mean BP (mmHg) | 108±2 | 105±3 | 109±4 | 134±5* | 100±3 | 139±4* |
| Renal VC ((kHz mmHg−1)103) | 68±8 | 69±5 | 77±10 | 46±7* | 89±10 | 67±9* |
| Mesenteric VC ((kHz mmHg −1)103) | 65±6 | 62±5 | 89±9 | 41±5* | 77±7 | 36±3* |
| Hindquarters VC ((kHz mmHg−1)103) | 38±4 | 37±4 | 35±5 | 18±2* | 31±2 | 18±1* |
All values are mean±s.e.m. for measurements 90 min after the onset of treatment, immediately prior to administration of hUII. VC=vascular conductance. Rats were given vehicle on day 1 and indomethacin (Indo, Group 1), L-NAME (Group 2) or AII plus AVP (Group 3) on day 3.
*
P⩽0.05 vs day 1 (Wilcoxon's test).