Original tracings showing the effects of the Rho-kinase inhibitor Y-27632 (10−6–5 × 10−5 M) on EFS (60 V, 1 mS, 8, 16, 32 Hz, 20 S, upper panel)-elicited and spontaneous (lower panel) contractions in the helical strips of the sheep ureter. Note that Y-27632 suppresses not only EFS-induced contractions but also spontaneous contractile activity.