Dynamic domain motions in (a) the first and (b) second JAM mode. The residues shown in blue, red, and green represent fixed-domain, moving-domain, and bending residues, respectively, as determined by dyndom (24). The arrows represent the axes of domain motions. The moving-domains rotate around these axes. The residues in the fixed domain are (a) Gly-11–Gln-25, Lys-34–Tyr-81, Lys-91–Asn-92, Leu-94–Lys-101, and (b) Gly-11–Phe-47, Phe-54–Lys-101. Those in moving domain are (a) Met-26–Ile-33, Lys-82–Gly-90, Val-93 and (b) Arg-48–Thr-53. Bending residues are (a) Gln-25–Met-26, Asp-32–Lys-34, Tyr-81–Lys-82, Gly-90–Leu-94 and (b) Gln-46–Arg-48, Thr-53–Phe-54. The residues that act as a mechanical hinge are (a) Asp-32, Ile-33, Lys-34, Lys-82 and (b) Gln-46, Phe-47, Arg-48, Thr-53, and Phe-54. The figure was created by using the programs dyndom (24) and rasmol (28).