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The CD2 surface flattens upon CD58 binding (in stereo). Substates 1 and 2 of free CD2 are shown in white and yellow, respectively. The crystal structure of the hCD2, which is a crystallographic homodimer (14) and the CD2/CD58 heterodimer (17) are shown in dark and light blue, respectively. The figure was prepared with insight ii (Molecular Simulations, Waltham, MA).
