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. 2004 Oct 4;143(5):626–637. doi: 10.1038/sj.bjp.0705900

Table 1.

Kd and Ki for the chicken MC1, MC3, MC4 and MC5 receptors obtained from competition experiments, together with previously published results for the human MC receptors

Ligand cMC1 (nmol l−1) hMC1a (nmol l−1) cMC3 (nmol l−1) hMC3b (nmol l−1) cMC4 (nmol l−1) hMC4b (nmol l−1) cMC5 (nmol l−1) hMC5c (nmol l−1)
[125I]NDP-MSH (Kd) 2.76±0.41 0.109±0.0062 0.139±0.019 0.412±0.121 1.84±0.23 1.78±0.36 0.45±0.15 5.05±1.00
NDP-MSH (Ki) 4.25±1.42 0.046±0.011 0.31±0.11 0.319±0.064 2.47±1.12 1.96±0.39 0.84±0.18 2.39±0.10
α-MSH (Ki) 363±72.7 0.210±0.089 24.0±0.30 21.2±5.3 40.6±18.0 522±122 189±58.5 8240±1670
Desacetyl α-MSH (Ki) 70.0±2.78 0.279±0.084d 1.62±0.24 13.9±4.8d 41.7±11.0 250±150d 47.3±4.04 1890±750d
β-MSH (Ki) 346±362 2.53±0.93 151±35.6 15.1±3.4 50.2±15.1 387±208 166±22.1 14400±1670
γ1-MSH (Ki) 1039±393 2.68±0.35c 3.40±0.61 7.45±2.55 586±58.8 51 800±12000 654±7.5 42 600±6600
ACTH(1–39) (Ki) 806±65 3.95±0.67d 15.4±0.2 135±22d 88.4±26.9 2170±120d 107±26 4920±610d
ACTH(1–24) (Ki) 65.7±8.34 0.209±0.052d 3.69±0.86 32.8±6.7 7.48±0.54 755±151 5.36±0.69 2760±780d
ACTH(1–17) (Ki) 17.1±4.82 0.230±0.061d 0.20±0.055 14±4.5d 2.01±0.38 419±62d 6.56±2.57 4240±1200d
ACTH(1–16) (Ki) 37.0±11.8 0.267±0.116d 0.51±0.13 19±4.3d 5.18±0.22 698±88d 16.1±1.31 2600±595d
MTII (Ki) 54.2±10.1 0.686±0.109e 12.7±1.66 52.6±7.9 2.04±0.53 39.7±6.7 70.7±6.91 46.1±7.9e
HS014 (Ki) 217±30.8 108±62f 483±62.1 64.1±12.5 5.44±1.41 3.41±1.31 1569±124 694±237f
HS024 (Ki) 28.3±6.12 18.6±3.3e 6.90±0.79 15.1±3.0 0.62±0.30 0.341±0.089 72.4±15.6 3.29±1.15e
a

Data taken from Schiöth et al. (1997b).

b

Data taken from Schiöth et al. (2002).

c

Data taken from Schiöth et al. (1995).

d

Data taken from Schiöth et al. (1997a).

e

Data taken from Kask et al. (1998).

f

Data taken from Schiöth et al. (1998).