Table 2.
Intracellular response in the form of EC50 values (means±s.e.m.) obtained for the chicken MC receptors on exposure to endogenous agonists; α-MSH and ACTH(1–24) as well as a synthetic agonist (MTII) and antagonist (HS024)
| Ligand | cMC1 (nM) | cMC2 (nM) | cMC3 (nM) | cMC4 (nM) | cMC5 (nM) |
|---|---|---|---|---|---|
| α-MSH | 3.80±0.64 | NS | 2.22±0.45 | 3.13±0.59 | 2.63±0.23 |
| ACTH(1–24) | 9.29±2.90 | 16.7±2.03 | 4.90±1.11 | 2.84±0.32 | 4.56±2.16 |
| MTII | 2.90±1.33 | ND | 2.72±0.59 | 1.41±0.49 | 11.9±2.81 |
| HS024 | 9.58±2.01 | ND | NS | NS | 68.0±0.86 |
NS: no stimulation; ND: not determined.