Table 3.

Effects of carcinine on the learning deficit induced by scopolamine (1 mg kg⁻¹) as evaluated by passive avoidance test in mice

Drug	Dose	Training trial	Test trial
Saline+saline	—	8.0±4.3	288.0±36.0
Scopolamine+saline	1 mg kg−1, i.p.	8.2±3.5	56.6±29.5**
Scopolamine+thioperamine	10 mg kg−1, i.p.	9.2±4.2	216.7±62.8#
Scopolamine+carcinine	5 mg kg−1, i.p.	7.8±3.3	75.6±27.6
	10 mg kg−1, i.p.	6.9±3.0	105.8±38.8
	20 mg kg−1, i.p.	7.2±4.4	156.6±70.2#
Scopolamine+carcinine	20 mg kg−1, i.p.
+(R)-α-methylhistamine	1 μg, i.c.v.	8.0±2.6	108.3±47.1
	2 μg, i.c.v.	7.7±2.9	58.9±24.7&
	5 μg, i.c.v.	8.2±3.5	32.1±14.2&&
Scopolamine+carcinine	20 mg kg−1, i.p.
+α-fluoromethylhistidine	10 mg kg−1, i.p.	10.6±4.5	80.6±43.7
	20 mg kg−1, i.p.	9.3±3.3	50.0±29.8&

Each value is expressed as the mean±s.d. of 15 to 18 rats.

^**P<0.01 represents statistically significant difference as compared to the saline+saline control group.

^#P<0.05 represents statistically significant difference as compared to the scopolamine+saline group.

^&P<0.05

^&&P<0.01 represent statistically significant difference as compared to the scopolamine+carcinine (20 mg kg⁻¹)-treated group.