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. 2006 Sep 22;2(9):e148. doi: 10.1371/journal.pgen.0020148

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) The elevation of relative recombination rate around defined hotspots on the short (blue) and long (red) arms of Chromosome 20.

(B) Elevation of relative diversity around hotspots (the black line is a smoothed average of the two arms).

(C) There is no effect of hotspots on relative divergence.

(D) Hotspots are associated with local increases in relative GC content. Note that a relative scale was used because the long and short arms can have systematic differences in absolute value.