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Tyrosine-phosphorylated p62dok inhibits RasGAP activity. (a) In vivo phosphorylated wild-type Dok-1 by p210bcr-abl inhibits GAP activity toward Ras. However, a mutant Dok-1 that does not bind to GAP has no effect on GAP activity. (b) In vitro-phosphorylated Dok-1 by Abl tyrosine kinase also inhibits GAP activity, whereas a mutant Dok-1 has no effect. v, vector only; W, wild-type p62dok; M, five-tyrosine mutant p62dok.
