Table 1.
Repeated CGRP infusion and TES
| Infusion or TES no. | 1 | 2 | 3 | 4 | 5 | 6 | 7 | P= |
|---|---|---|---|---|---|---|---|---|
| r-αCGRP (n=4) | ||||||||
| ΔMABP (mmHg) | −25.6±4.4 | −23.1±4.6 | −22.5±4 | −23.9±0.7 | −26.8±4.1 | −28.5±3.9 | −29.6±6 | 0.3 |
| ΔDura (%) | 88.5±21.7 | 91.6±22.8 | 86.6±20.4 | 83.2±18 | 82.3±15.5 | 90.7±21.5 | 89.1±21.3 | 0.5 |
| ΔPia (%) | 28.6±11.6 | 32.6±15.2 | 30.4±12.6 | 32.4±17.8 | 29.3±9.8 | 26.8±8.7 | 34.3±17.9 | 0.8 |
| ΔLCBFFlux(%) | 30.5±8.5 | 31.5±7.9 | 28.6±9.3 | 29.9±8.9 | 28±5.7 | 26.7±6.6 | 27.9±6.5 | 0.5 |
| r-βCGRP (n=6) | ||||||||
| ΔMABP (mmHg) | −15.4±1.6 | −18.6±3.2 | −17.8±2.8 | −21.5±2.7 | −17.3±2.3 | −20.4±3.2 | −20.8±3 | 0.2 |
| ΔDura (%) | 105.9±16.8 | 105.5±19.5 | 108.7±18.1 | 104.5±13.6 | 109.7±13.5 | 113.9±18.7 | 112.3±14.9 | 0.9 |
| ΔPia (%) | 16.7±2.7 | 18.9±3 | 15.4±2.5 | 21.1±4.3 | 20±4.1 | 17.3±2.7 | 22±5.2 | 0.4 |
| ΔLCBFFlux(%) | 17.4±1.5 | 19.4±4.1 | 20.1±2.8 | 25±3.1 | 20.1±2.5 | 20.5±1.7 | 20.3±1.6 | 0.2 |
| TES (n=6) | ||||||||
| ΔMABP (mmHg) | −3.6±2.4 | −4.9±2.3 | −2.5±1.9 | −3.3±2 | −4.9±2.2 | −3.2±2.6 | −2.6±2.5 | 0.2 |
| ΔDura (%) | 131.8±13.3 | 125.2±12 | 130.9±14.1 | 140.5±10.9 | 137.5±13.4 | 130.5±9.4 | 133.5±11.1 | 0.5 |
| ΔPia (%) | 69±13.7 | 66.4±13.5 | 72.9±16.9 | 68.9±13.5 | 64.4±14.2 | 57±16.6 | 56±14.4 | 0.2 |
Percentual or mmHg change from baseline of the seven consecutive infusions of αCGRP, βCGRP or stimulations. Data are listed as mean±s.e.m. The P-values are the statistical comparison between the different infusions and stimulations (ANOVA).