Table 2.
Correlation between published antagonist affinities for α1A-, α1B- and α1D- adrenoceptor ligand binding sites (see Honner & Docherty for affinity values of nine antagonists; additional values for RS 100329 taken from Williams et al., 1999) and antagonist affinities for ligand binding in rat vas deferens (Table 1), using both high- and low-affinity values obtained for BMY 7378
| α1A | α1B | α1D | |
|---|---|---|---|
| BMY 7378 high-affinity site (9.20) | |||
| r | 0.23 | 0.17 | 0.78 |
| Significance | NS | NS | P<0.01 |
| BMY 7378 low-affinity site (7.17) | |||
| r | 0.78 | 0.47 | 0.57 |
| Significance | P<0.01 | NS | NS |
NS=not significant.