Table 4.

The effect of morphine pellet treatment (72 h) on gene expression in brain and spinal cord

	Brain			Spinal cord
Gene	Placebo	Morphine tolerant	P	Placebo	Morphine tolerant	P
MOR	7.08±0.10	6.68±0.32	0.33	5.85±0.45	5.91±0.23	0.82
DOR	6.02±0.23	6.13±0.18	0.72	6.47±0.40	6.17±0.25	0.62
KOR	7.10±0.19	7.20±0.17	0.72	6.88±0.22	6.96±0.24	0.87
PPE	1.60±0.24	1.30±0.16	0.32	1.64±0.14	1.41±0.20	0.48
PPD	6.22±0.19	5.97±0.20	0.40	7.07±0.14	6.82±0.20	0.43
POMC	8.58±0.48	9.35±0.38	0.24	10.81±0.17	11.18±0.30	0.28

Data are given as mean±s.e.m. of ΔC_T values, n=5. P-values, morphine-tolerant mice compared to placebo mice, were determined by t-test.