Figure 4.

Haloperidol block of K_ATP currents in HEK293 cells is voltage independent. (a) Effect of 10 μM haloperidol on Kir6.2/SUR1 K_ATP channels expressed in HEK cells. Currents (lower trace) were elicited by ±50 mV voltage steps from a holding potential of −68 mV (top trace), which is the calculated E_K. (b) The time course of haloperidol block of both −50 mV (inward current) and +50 mV (outward current). (c) The inhibition by 10 μM haloperidol at +50 mV (67±14%) and −50 mV (67±13%) was not significantly different (n=3, P=0.82, paired t-test).