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. 2004 Nov 8;143(8):960–967. doi: 10.1038/sj.bjp.0706017

Figure 5.

Figure 5

[K+]o reduced the haloperidol effect on KATP conductances in mouse pancreatic β cells. (a). Haloperidol concentration-dependent inhibition curves were constructed at different [K+]o (see Results for details on whole-cell KATP conductance measurements). The number of cells tested at each [K+]o was between 2 and 12 (median=5). Dashed lines were fitted by the Hill equation. (b) IC50 values for haloperidol blockage determined from the concentration-dependent inhibition curves shown in (a). Calculated values were 1.67±0.25, 3.06±0.65, 8.97±0.95, 14.84±2.75, and 23.88±2.21 for 2, 10, 50, 100, 150 mM [K+]o, respectively. (c) Hill coefficients for haloperidol block determined from the concentration-dependent inhibition curves shown in (a). Calculated values were 0.72±0.07, 0.62±0.09, 0,84±0.07, 0.68±0.10, and 0.75±0.06 for 2, 10, 50, 100, 150 mM [K+]o, respectively.