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BW284c51 effects on Ach- and Cch-elicited currents. Recordings show nicotinic currents elicited in the same oocyte by 100 μM Ach either alone (pre- and post-control responses) or together with 0.5 μM BW284c51 (a), and by 100 μM Cch either alone (pre- and post-control responses) or coapplied with 0.5 μM BW284c51 (b). Note that as for IAch, BW284c51 blocked about half of the Cch-induced current. In both cases, the blockade was fully reversible upon removal of BW284c51.
