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. 2004 Nov 22;144(1):88–97. doi: 10.1038/sj.bjp.0705965

Figure 8.

Figure 8

Voltage dependence of BW284c51 effects on IAch. (a) The i–v relationship for the IAch, elicited by 10 μM Ach either alone or coapplied with 0.5 μM BW284c51, was obtained by giving voltage pulses from −120 up to +60 mV, in 20 mV steps, during the current plateau induced by Ach. Values were normalised, for each oocyte, as the percentage of the IAch obtained at −60 mV while superfusing it with Ach alone. Every point is the mean±s.e.m. of five oocytes from two donors. Note that the blocking effect of BW284c51 vanished at positive potentials. The inset shows the IAch plateau elicited by 10 μM Ach and the time at which voltage pulses were given. (b) Effect of a 10 s depolarising pulse (from the holding potential, −60 mV, up to +40 mV) on the IAch elicited by 10 μM Ach either alone or coapplied with 0.5 μM BW284c51. Note that IAch blockade by BW284c51 was completely abolished at +40 mV and that once the depolarising pulse had finished, the blocking action of BW284c51 was immediately, and completely, recovered.