Table 1.
General and hemodynamic characteristics of animals with CHF with or without imidapril treatment
| Parameter | Sham | Sham+IMP | MI | MI+IMP |
|---|---|---|---|---|
| Body wt (g) | 522±17 | 452±8 | 487±11 | 470±15 |
| RV wt (mg) | 263±10 | 270±20 | 580±12* | 384±10† |
| Scar wt (mg) | ND | ND | 237±28 | 241±20 |
| Viable LV wt (mg) | 902±22 | 900±40 | 1129±30* | 1018±12† |
| Heart wt/body wt (mg g−1) | 2.4±0.3 | 2.5±0.4 | 3.58±0.1* | 2.8±0.3† |
| Heart rate (beats min−1) | 284±13 | 251±17 | 284±23 | 294±10 |
| MAP (mmHg) | 106±5 | 102±4 | 98±5 | 96±7 |
| LVEDP (mmHg) | 3.4±0.4 | 3.2±0.5 | 14.9±0.8* | 6.3±0.4† |
| LVDP (mmHg) | 120±7 | 125±7 | 110±9 | 120±12 |
| +dP/dt (mmHg s−1) | 9500±500 | 7500±800 | 4243±788* | 6665±941† |
| −dP/dt, (mmHg s−1) | 9700±600 | 9200±400 | 4145±478* | 9620±1184† |
Values are mean±s.e.m. of five animals for each group. The viable left ventricle (LV) wt of the experimental animals refers to the weight of the LV plus septum after removal of the scar tissue. Sham, operated but the coronary artery was not ligated; MI, myocardial infarcted with coronary artery ligated; IMP, imidapril was given orally (1 mg kg−1 day−1) starting at the end of 3rd week following the surgery and continued for 5 weeks; RV, right ventricle; MAP, mean arterial pressure; LVEDP, left ventricular end diastolic pressure; LVDP, left ventricular developed pressure; +dP/dt, maximum rate of pressure development; −dP/dt, maximum rate of pressure decay; ND, not detectable;
P<0.05 vs sham control value;
P<0.05 vs MI value.