Table 3.

Increase in [Ca²⁺]_i in cardiomyocytes due to different concentrations of ATP in animals with CHF with or without imidapril treatment

	Increase in intracellular concentration of Ca2+ (% of basal)
ATP (μM)	Sham	MI	MI+IMP
5	6±0.4	2.3±0.3*	5.2±0.2†
10	14±0.8	5.1±0.7*	11.1±0.6†
25	21±1.7	7.5±1.1*	14.8±0.9†
50	36±2.3	13.8±0.8*	28.5±1.4†
100	44±3.5	15.2±0.6*	27.6±1.7†

Values are mean±s.e.m. of four animals in each group. The basal value for [Ca²⁺]_i in cardiomyocytes varied between 108 and 125 nM Ca²⁺ and there was no difference (P<0.05) among groups. The increase in [Ca²⁺]_i was measured 100 s after the addition of ATP. Sham, operated but not ligated; MI, myocardial infarcted with coronary artery ligated; imidapril (IMP) was given orally (1 mg kg⁻¹ day⁻¹).

^*P<0.05 vs sham control value;

^†P<0.05 vs MI value.