Figure 3.

Depletion of intracellular Ca²⁺ stores alters contractile tension responses to 5-HT. (a) 5-HT (5 μM) -induced increase in arterial ring tension in the absence (solid line) or presence (dashed line) of 20 μM CPA. (b) 5-HT (5 μM) -increase in arterial ring tension in the absence (solid line) or presence (dashed line) of 10 μM ryanodine. (c) Caffeine (15 mM) -induced increase in arterial ring tension in the absence (solid line) or presence (dashed line) of 10 μM ryanodine. (d) Mean change in artery tension due to 5-HT or caffeine in the presence of CPA or ryanodine. Error bars represent±s.e.m. ^*Means significantly different from their control values by a two-tailed paired t-test (P<0.05).