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Ni2+ but not nisoldipine or Gd3+ reduces the rate of Mn2+ entry in canine PASMCs. (a) Effect of 10 mM Ni2+ on fura-2 quench by Mn2+. (b) Effect of 10 μM nisoldipine on fura-2 quench by Mn2+. (c) Effect of 100 μM Gd3+ on fura-2 quench by Mn2+. (d) Percent change in fura-2 quench rate by Mn2+ compared to control. Agonists were present at times shown by the bars. Error bars represent±s.e.m. *Means significantly different from their controls by a two-tailed paired t-test (P<0.05).
