Figure 3.

Effect of chronic treatment with the ACEI, captopril (100 mg kg⁻¹ day⁻¹, full columns) on CSA of the vessel wall, external diameter (ED), WT and WT/ID in young (6 months) and old (15 months) SHR compared to age-matched normotensive WKY. External diameter was measured in maximally dilated cerebral arterioles (EDTA) for pressure steps of 30–35 mmHg. WT and WT/ID were calculated from values of CSA and ID measured in maximally dilated cerebral arterioles (EDTA) for pressure steps of 30–35 mmHg. ^*P⩽0.05 versus age-matched WKY. ^†P⩽0.05 versus age-matched SHR.