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. 2005 Jan 17;144(3):308–316. doi: 10.1038/sj.bjp.0706041

Figure 3.

Figure 3

Effects of PPAR agonist intervention therapy in ZDF (+/+) DIO rats. (a) S-S blood glucose concentration, (b) GIR and (c) incremental change from baseline in insulin secretion during the hyperglycaemic clamp. Animals were treated once daily for 28 days with RAGA (1.5 mg kg−1), PIO (30 mg kg−1) and BF (100 mg kg−1), then clamped at 24 mM glucose, as described in Methods. Vehicle-treated DIO (CON) and lean (CHOW) rats were used as controls. Values are expressed as mean±s.e.m. (n=8); *P<0.05 as compared to CON (ANOVA).