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Inhibition of recombinant NR1a+2B NMDA receptors by 5-HT and related indolealkylamines
| Indolealkylamine | IC50 (μM) −120 mV | H | IC50 (μM) −70 mV | H | n |
|---|---|---|---|---|---|
| 5-HT | 49±2.9 | 1.0±0.1 | 286±15 | 1.3±0.1 | 8 |
| 7-Methyltryptamine | 46±6.1 | 0.9±0.3 | 167±7.8 | 0.9±0.3 | 5 |
| Tryptamine | 32±2.5 | 1.3±0.2 | 138±3.6 | 1.1±0.3 | 6 |
| 5-Methyltryptamine | 3.5±0.1 | 1.1±0.1 | 29±3.0 | 1.6±0.2 | 5 |
| 5-MeOT | 3.6±0.4 | 1.0±0.1 | 18±1.8 | 1.2±0.1 | 6 |
