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Time course of changes in MLDF in response to vehicle or PD123319 treatment in (a) sham and (b) 2K1C hypertensive rats. Data indicate percentage changes relative to control over 5 min intervals following commencement of antagonist infusion. Lines and error bars represent mean±s.e.m. (n=6 per group). ###P<0.001 for main effect of PD123319 treatment from analysis of variance.
