Table 1.
Potencies of bimatoprost, 17-phenyl PGF2α, PGF2α, latanoprost free acid, and latanoprost
| Preparation | Bimatoprost (pEC50) | 17-phenyl PGF2α (pEC50) | PGF2α (pEC50) | Latanoprost free acid (pEC50) | Latanoprost (pEC50) |
|---|---|---|---|---|---|
| Rabbit uterus | 7.92±0.16 | 9.17±0.06 | 8.09±0.15 | 8.23±0.19 | 6.58±0.15 |
| Mouse uterus | <5 | 8.15±0.11 | 7.57±0.27 | 7.53±0.21 | 6.30±0.11 |
| Rat uterus | <5 | 8.18±0.11 | 7.06±0.07 | nt | nt |
| Rabbit intact jugular vein | 5.4* | 8.27±0.30 | 8.51±0.18 | nt | nt |
| Swiss 3T3 fibroblasts | Not active | 7.62±0.26 | 7.22±0.13 | nt | nt |
Mean pEC50 value±s.e.m. for isolated uterus of rabbit, mouse, rat (contraction), isolated endothelium-intact precontracted jugular vein of rabbit (vasorelaxation), and cultured Swiss 3T3 fibroblasts (stimulation of DNA synthesis). nt=not tested.
*
pEC50 value was obtained from the mean concentration–response curve because some tissues did not reach the 50% response level.