Cumulative concentration–response curves to purine and pyrimidine agonists on AVP (10 nM) precontracted urethral strips. (a) Concentration–response curves to 2-MeSADP, 2-MeSATP, α,β-meATP and β,γ-meATP (all 0.1 μM–1 mM). (b) Concentration–response curves to TTP, CTP, UTP, GTP and UDP (all 0.1 μM–1 mM). All points show the mean±s.e.m. of six to eight experiments, unless occluded by the symbol.