Figure 7.
Effects of lumiracoxib and diclofenac treatment on clinical severity of adjuvant-induced arthritis. (a) Rats were injected with M. tuberculosis and arranged into groups of equal severity on day 14. Rats were treated daily with lumiracoxib or diclofenac for 4 consecutive days. Values represent the mean percent inhibition (±s.e.m.) of paw volume 24 h after the final dose of compounds (mean from two experiments, n=4 rats per treatment group in each experiment). (b) Rats were injected with adjuvant on day 1 and treated with lumiracoxib or diclofenac (both at 2 mg kg−1) once daily from day 12 until termination of the experiment. Arthritis and normal control rats were given vehicle alone. Paw volumes were measured periodically during the course of disease. Values shown are mean volumes±s.e.m. (mean from four experiments, n=6 rats per treatment group in each experiment).