Table 1.
Ki values for inhibition of [3H]glibenclamide binding to membranes expressing SUR1, Kir6.2/SUR1 and Kir6.2ΔN14/SUR1
| SUR1 Ki (nM) | Kir6.2/SUR1 Ki (nM) | Kir6.2ΔN14/SUR1 Ki (nM) | |
|---|---|---|---|
| Repaglinide | 72±9 | Site 1: 0.06±0.03 | 51±10 |
| Site 2: 28±9 | |||
| Glibenclamide | 3.8±1.9NS | 0.8±0.3 | 2.4±2.0NS |
| Tolbutamide | 79,000±6000* | 33,000±1000 | 48,000±1000* |
| Nateglinide | 2100±100* | 730±50 | 1200±30* |
Data are means±s.e.m. (n=3–5).
pKi values significantly different from Kir6.2/SUR1,
*
P<0.005 (t-test).
NS=not significantly different from Kir6.2/SUR1.