Table 1.

Comparison of pEC₅₀ values, maximum responses and Hill slopes for agonists producing contractions in (a) control, (b) α_1B-KO and (c) α_1D-KO mouse carotid arteries

Agonist	pEC50	Max. response (g)	Hill slope (95% CI)
(a) Control
PE	6.3±0.06	0.37±0.01	0.5 (0.4–0.6)#
(R)-A-61603	6.9±0.09	0.27±0.01	0.65 (0.5–0.8)#
5-HT	6.9±0.08	0.27±0.04	1.15 (0.6–1.7)
(b) α1B-KO
PE	6.9±0.22*	0.33±0.01	0.4 (0.2–0.6)#
(R)-A-61603	6.7±0.07	0.28±0.01	0.65 (0.5–0.8)#
5-HT	6.8±0.04	0.27±0.05	1.3 (0.9–1.7)
(c) α1D-KO
PE	5.5±0.07*	0.21±0.02*	0.85 (0.6–1.1)
(R)-A-61603	7.4±0.27*	0.11±0.01*	0.4 (0.1–0.7)#
5-HT	7.4±0.05*	0.26±0.06	1.0 (0.7–1.3)

pEC₅₀ values and maximum responses are expressed as mean±s.e.m. and the Hill slopes are given along with their 95% confidence intervals (95% CI).

^*P<0.05 compared to control;

^#Hill slope significantly different from unity.