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pA2 or pKB values and slope parameters of antagonists in control, α1B-KO or α1D-KO mouse carotid arteries
| Control | α1B-KO | α1D-KO | ||||
|---|---|---|---|---|---|---|
| Antagonist | pA2/pKB | Slope | pA2/pKB | Slope | pA2/pKB | Slope |
| Prazosin | 9.6 | 0.93 (0.77–1.08) | 10.3 | 0.92 (0.68–1.2) | 10.6 | NA |
| 5-MeU | 7.5 | 1.1 (0.73–1.5) | 7.6 | 1.1 (0.77–1.5) | 8.1 | 0.82 (0.4–1.3) |
| BMY7378 | 8.3 | NA | 9.6 | 0.9 | 7.0 | NA |
CRCs were constructed to PE. Values in parentheses are the 95% confidence limits for the slope value. 5-MeU, 5-methylurapidil; NA, not applicable.
