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Effects of SV on tonic contractions induced by ET-1, NA and KCl. Aortic rings were precontracted with either ET-1 (10 nM), NA (0.1 μM), or KCl (60 mM) prior to obtaining cumulative concentration–response curves to SV. Results are expressed as a percentage of maximum tonic contraction produced by the vasoconstrictors, and are expressed as means±s.e.m. for experiments with 10 or more rings.
