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Effects of mevalonate on relaxation mediated by SV in rat aortic rings precontracted with ET-1. Aortic rings were pretreated with either mevalonate (200 μM) or vehicle for 2 h, and then precontracted with ET-1 (10 nM) prior to obtaining cumulative concentration–effect curves for SV. Results are expressed as a percentage of the maximum tonic contraction to ET-1, and are presented as means±s.e.m. for experiments with six rings.
