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Effects of HA-1077 on tonic contractions developed in response to ET-1, NA and KCl. HA-1077 was administered in increasing cumulative concentrations (0.1–1 μM) to preparations, in which tonic contractions to the vasoconstrictors had developed. Results are expressed as a percentage of maximum tonic contraction produced by either ET-1 (10 nM), NA (0.1 μM) or KCl (60 mM), and are presented as means±s.e.m. for experiments with six rings.
