Figure 6.

Effects of nimodipine on tonic contraction developed in response to ET-1, NA and KCl. Aortic rings were precontracted with either ET-1 (10 nM), NA (0.1 μM) or KCl (60 mM) and nimodipine was administered in increasing cumulative concentrations (0.1 nM–1 μM) to preparations in which tonic contractions to the vasoconstrictors had developed. Results are expressed as a percentage of maximum tonic contraction produced by ET-1, NA or KCl, and are presented as means±s.e.m. for experiments with six rings.