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. 2005 Jan 31;144(6):781–790. doi: 10.1038/sj.bjp.0706040

Figure 4.

Figure 4

Modulation of the piperine-activated TRPV1 current by acid. (a) A typical recording trace showing the dramatic potentiation of a capsaicin-(1 μM, black bar)-mediated TRPV1 response by extracellular acidification from pH 7.3 to pH 6.5 (grey bar). In these experiments, pH 6.5 was selected for study as it is a subagonist pH versus TRPV1 (data not shown). pH 6.5 potentiated the capsaicin response by 284±32% (n=8). (b) A similar protocol was employed to study the effects of acidification on the piperine response. Switching from pH 7.30 to pH 6.5 potentiated the piperine-(30 μM gated response, white bar) by 230±20% (n=11) (c) Pooled data showing that capsaicin and piperine are similarly modulated by acid (pH 6.5). The data are expressed as a percentage of the mean current recorded in response to the agonist at pH 7.3.