Figure 2.

Agonist dose–antinociceptive response curves (single agonist administration s.c.) in the (a) hot plate and (b) tail flick assays in conscious mice. Responses are expressed as %MPE (see Methods). %MPE values at the time point at which peak antinociceptive responses were observed for each respective agonist (see Figure 1) were used to plot the curves. The total n values for each agonist curve in the hot plate and tail flick assays, respectively, were as follows: CP55,940 n=50 and 33; dexmedetomidine n=57 and 46; and morphine n=34 and 40. For each agonist dose, n values in the hot plate and tail flick assays, respectively, were as follows: CP55,940 n=8–16 and 7–11; dexmedetomidine n=10–12 and 6–12; and morphine n=6–8 and 6–12. Symbols are mean±s.e.m.