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Summary of effects of V102862, PHT, CBZ and LTG on rNav1.2 channels in HEK-293 cells
| KR (μM) | KI (μM) | k+ (μM−1 s−1) | τrepr (ms) | |
|---|---|---|---|---|
| V102862 | 29±3 (5) | 0.37±0.01 (4) | ∼1.7 (4) | 680±43 (16) |
| PHT | 1400±100 (3) | 20±2 (3) | ∼0.018 (3) | 109+13 (3) |
| CBZ | 1300±100 (5) | 46±5 (5) | ∼0.045 (4) | 20±1 (3) |
| LTG | 1800±250 (5) | 29±3 (3) | ∼0.024 (4) | 64±3 (3) |
