Figure 1.
Expression of mRNA of D1 and D2 receptors in the prefrontal cortex of saline- and simvastatin-treated rats. RT–PCR showed that simvastatin (sim, 10 or 30 mg kg−1 day−1) increased D1 and D2 receptor mRNA expression by about 1.8- and 2.4-fold, respectively, in the prefrontal cortex when compared to the saline-treated control (C) group. No changes were observed with sim treatment at 1 mg kg−1 day−1. Graphs showed band intensity relative to the corresponding β-actin band. Error bars represent s.e.m., n=6 per group. One-way ANOVA: F(3,16)=85.607, P<0.001 for D1 and F(3,16)=30.793, P<0.001 for D2. ***P<0.001 by post hoc analysis with Bonferroni correction. Top panel shows typical bands of β-actin, D1 and D2 receptors in the same order (left to right) as presented in the graph.