Figure 6.

Effects of D₁ and D₂ receptor activation on cAMP levels in synaptosomes prepared from the prefrontal cortex of saline- and simvastatin-treated rats. Synaptosomal preparations were obtained from the prefrontal cortex of rats treated with saline or simvastatin (10 mg kg⁻¹ day⁻¹) and then incubated with various drugs as indicated. cAMP levels were determined as described in text. Sal=saline, Quin=quinpirole (5 μM), CAPB=chloro-APB (5 μM), SCH=SCH-23390 (25 μM), n=4–14 per group, total n=65. Statistical analysis was performed using general linear model multivariate analysis: pretreatment (control vs simvastatin-treated rats): F(1,55)=22.202, P<0.001; drug treatment: F(4,55)=23.502, P<0.001; interaction: F(4,55)=5.234, P<0.002. ^*** or ^†††P<0.001 against corresponding Sal, Quin and CAPB/Quin groups, and ^* or ^†P<0.05 against corresponding Sal, Quin and CAPB groups by post hoc analysis with Bonferroni correction.