Table 2.

Cardiac variables in control, Ovx, and Ovx+E₂ groups

Variables	Baseline	Isoprenaline (10−8 M)	Fold-increase
LVDP (mmHg)
Con	121±9	162±11	1.3±0.7
Ovx	181±12*	452±23*	2.5±0.6*
Ovx+E2	116±8	164±12	1.4±0.4
LVEDP (mmHg)
Con	10±1.4	11±1.6	1.1±0.2
Ovx	11±2.1	10.6±1.8	0.9±0.1
Ovx+E2	10±1.8	12.3±1.9	1.2±0.3
+dp/dtmax (mmHg/s)
Con	2137±72	4274±83	2±0.2
Ovx	2991±65*	8973±96*	3±0.3*
Ovx+E2	2230±71	4727±75	2.1±0.3
−dp/dtmax (mmHg/s)
Con	1659±47	3318±76	2±0.2
Ovx	2654±36*	8492±101*	3.2±0.3*
Ovx+E2	1780±38	4094±65	2.3±0.4
HR (beats/min)
Con	221±17	354±12	1.2±0.5
Ovx	230±15	377±18*	1.64±0.6*
Ovx+E2	232±12	362±14	1.2±0.5

Values are expressed as mean±s.e.m. (n=8 in each group).

+dp/dt_max, the velocity of contraction; −dp/dt_max, the velocity of relaxation, LVDP, left ventricular developed pressure; LVEDP, left ventricular end diastolic pressure; HR, heart rate.

^*P<0.05 vs Con.