Figure 5.
Effect of prenatal cocaine exposure on postischemic recovery of LV function in 1 month-old rats. Hearts were obtained from 30-day-old neonates that were exposed to either saline control or cocaine (30 mg kg−1 day−1) before birth from days 15 to 21 of gestational age, and were subjected to 25 min of ischemia and 60 min of reperfusion in the Langendorff preparation. LVDP, left ventricular developed pressure; HR, heart rate; PRP, pressure rate product (LVDP × HR); LVEDP, left ventricular end diastolic pressure; CF, coronary flow. Data were analyzed by two-way ANOVA with ischemia–reperfusion as one factor and cocaine treatment as the other. The asterisk (*) indicates a significant difference (P<0.05) from control for the entire curve. n=5.