Figure 5.

Effect of compounds on lipopolysaccharide-induced bronchoalveolar lavage neutrophilia. BALB/c mice were intranasally challenged with either phosphate-buffered saline (PBS) or lipopolysaccharide (LPS). Compounds or vehicle were given, intranasally or orally, 30 min or 1 h before the LPS challenge, respectively. Animals were killed 3 h after the challenge. Data are expressed as the mean±s.e.m. (n=8–10 mice per group). Significance versus vehicle-treated mice and LPS-challenged animals is indicated by ^*(P<0.05). Doses are in mg kg⁻¹.