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. 2005 Feb 14;144(8):1078–1088. doi: 10.1038/sj.bjp.0706142

Table 4.

Concentration-dependent inhibition of wild-type and mutant Kir6.2/SUR2 channels by GBC in inside-out patches

Channel IC50 (nM) A (%)
Kir6.2/SUR2Aa 26 (23, 29) 54±3
Kir6.2/SUR2A(YS) 0.83 (0.58, 1.2) 70±2
Kir6.2/SUR2Ba 27 (22, 32) 63±2
Kit6.2/SUR2B(YS) 1.0 (0.70, 1.5) 65±2

Parameters are from fits of the Hill's equation with nH=1 to the individual data points obtained as shown in Figure 5; mean values are presented in Figure 6. A=amplitude (extent of inhibition).

a

Data are from Russ et al. (2001).