Figure 4.
Effect of ketotifen on angiogenesis. Granuloma was induced by (1%) λ-carrageenin- or saline-soaked sponge implants in rats. Ketotifen fumarate (1–5–25 mg kg−1) was given intraperitoneally at time 0, that is, the same day of sponge implantation. Angiogenesis was evaluated at 96 h after implantation as (a) haemoglobin content in the tissue and (b) TNF-α levels in the exudates. Bars represent the mean±s.e. of n=4 experiments in duplicate. ***P<0.001 vs saline; °P<0.05 and °°°P<0.001 vs carrageenin alone.