Figure 2.

(a) Time-dependent effect of IFN-γ (1000 U ml⁻¹) on NHE activity in cultured Caco-2 cells. (b) Effect of cariporide (300 nM) and S-3226 (300 nM) on the IFN-γ- (1000 U ml⁻¹) induced inhibition of NHE activity in cultured Caco-2 cells. Concentration-dependent effect of IFN-γ (1000 U ml⁻¹) after (c) 0.5 h and (d) 24 h of exposure. Columns or symbols represent means of seven experiments per group; vertical lines indicate s.e.m. values. ^*P<0.05, values significantly different from control values using the Newman–Keuls test; ^#P<0.05, values significantly different from values with IFN-γ alone using the Newman–Keuls test.