Table 1.
pKi values for in vitro inhibition by oxybutynin, DEOB and solifenacin of specific [3H]-NMS binding in the bladder, submaxillary gland and heart of mice
| Drug | pKi value | ||
|---|---|---|---|
| Bladder | Submaxillary gland | Heart | |
| Oxybutynin | 7.80±0.03†† | 8.22±0.03**†† | 7.39±0.06**†† |
| (0.98±0.03) | (0.87±0.07) | (1.03±0.05) | |
| DEOB | 8.30±0.08†† | 9.00±0.05**†† | 7.80±0.02**†† |
| (0.84±0.09) | (0.78±0.04) | (1.08±0.03) | |
| Solifenacin | 7.38±0.03 | 7.89±0.03** | 7.00±0.03** |
| (0.95±0.03) | (0.90±0.02) | (1.00±0.06) |
Values are mean±s.e.m. of three or four mice. Values in parentheses represent Hill slopes. Asterisks show a significant difference from values in the bladder,
**
P<0.01. Daggers show a significant difference from the values with solifenacin,
††
P<0.01.